Before a new technology in the field of health care comes to market, it must be clinically tested (validated). As for this medical validation, biozoom works together with experts from various medical faculties.
As part of the definition of the level of antioxidants, we collaborate with, for example, Prof. Lademann, head of the Center of Experimental and Applied Cutaneous Physiology (CCP) at the Charité Hospital in Berlin. He is one of the leading experts in the field of non-invasive antioxidant measurement and has validated our device. In this study, measurements taken with the biozoom device were demonstrated in accordance with measurements made with a recognized reference system.
In the field of determining the Variability of Cardiac Frequency, biozoom collaborates with Prof. Dr. Thomas Loew, head of the department of Psychosomatic Medicine at the University Hospital of Regensburg. He is also head of the Department of Psychosomatic Medicine of the Donaustauf Clinic and since 2012 Vice-President of the Association of European Physicians for Psychosomatic Medicine (AEPM) “.
The results were published in the Journal of Biophotonics (1-9, 2012) (title: “Comparison of two methods for non-invasive determination of carotenoids in human and animal skin: Raman spectroscopy versus reflection spectroscopy”).
In the field of antioxidant measurement, we have been collaborating with Prof. Lademann for about 10 years. He is one of the world’s leading experts in the field of non-invasive antioxidant measurement. For this reason, biozoom has relied on Prof. Lademann for validating your scanner. In this study, measurements taken with the biozoom device were demonstrated in accordance with measurements made with a recognized reference system. The results were published in the Journal of Biophotonics (1-9, 2012) (title: “Comparison of two methods for non-invasive determination of carotenoids in human and animal skin: Raman spectroscopy versus reflection spectroscopy”).
Due to the validity of the measured values, the biozoom scanner is also tested for clinical use. Prof. Dr. Lademann uses the system, among other things, to study the “hand-foot disease” that can occur in chemotherapy as a result of the use of certain chemotherapy agents. Chemotherapy agents pass through sweat on the skin and lead to highly inflammatory processes, which need to be cured.
Testing the influence of diet, habits and sociocultural factors on the level of antioxidants was the central theme of another doctoral thesis.
Prof John of the University of Osnabrück successfully uses the system in the field of occupational medicine.
In a scientific study by Prof. Lademann/Charité Berlin with 50 students, it has been shown that measuring antioxidants leads to a positive change in the diet and lifestyle of the person making it, since the measurement result and the person’s behavior are directly linked. If changes in diet and lifestyle are positive, the measurement results increase accordingly, encouraging the user to maintain their new lifestyle, for example by eating more fruits to vegetables. If, however, these changes are not effective enough, the person will tend to adjust them until they get an improvement in the measurement values. In this way, the participating students improved their values within a month or so. To verify the continuity of these values, the students took the measurements again after six months and, compared to the beginning, the average of the values was slightly higher. In addition, 41% of smokers had quit smoking, as smokers usually have lower values than non-smokers. (See the “Journal of Biophotonics” 1-12, 2013 – headline: “Spectroscopic biofeedback on cutaneous carotenoids as part of a prevention program could be effective to raise health awareness in adolescents”). The results therefore show the degree of influence that bio-feedback measurement has on human behavior.
In a doctoral thesis at the University of Rostock, the antioxidant level of pregnant women and newborns was studied. It is known that during pregnancy and childbirth there tends to be an increase in free radicals. Up to 80% of neonatal deaths in the first month of life are caused by diseases associated with the formation of free radicals. It was discovered in this study that during labor and a day after birth, the mother’s antioxidant level decreases dramatically while the newborn has a significantly higher level. In some cases, the date of birth may even be provided with the help of measurements.
In another study by the University of Rostock, the effect of shiftwork in midwives was studied with the help of the biozoom measurement device. The result was an inverse correlation between stress due to shift work and antioxidant level. In other words, the greater the stress caused by shiftwork, the lower the antioxidant level of midwives.
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The fact that our measurement of antioxidants is medically and scientifically recognized internationally is also demonstrated by its use in NASA’s space program. The biozoom measurement devices are part of the Human Exploration Research Analogue (HERA) Campaign project and will be used in the United States for NASA’s next project in China “Effects of 30 days of Isolation and Confinement on Hippocampal Volume and Visuo-Spatial Memory”. The main objective is to study the impact of isolation in the HERA habitat on the structural and functional plasticity of the brain, cognitive performance and subjective well-being and their relationship with neurophysiological biomarkers. The projects are scientifically supported by the “Deutsches Zentrumf-rLuft- und Raumfahrt (DLR)”.
In this study, an improved method based on “Multiple spatially resolved reflection spectroscopy” (MSRRS) was introduced. The results were compared with those obtained using the ‘standard’ Raman resonance spectroscopy method and showed strong correlations for the total concentration of carotenoids (R-0.83) and for lycopene (R-0.80). The stability of the measurement was confirmed to be better than 10% in the total temperature range from 5 degrees C to 30 degrees C and the pressure contact between the skin and the MSRRS sensor from 800 Pa to 18000 Pa.